Description:

The 5th edition of the WHO Classification of Hematolymphoid Tumors PART 1: Myeloid and Histiocytic course provides an in-depth exploration of the classification of hematolymphoid tumors focusing on myeloid and histiocytic neoplasms following the guidelines set by the World Health Organization (WHO).

Key Highlights:

• Detailed insights into the updated WHO classification criteria
• Comprehensive review of myeloid and histiocytic tumors
• Case studies and practical applications to enhance understanding

What you will learn:

General Introduction to WHO series
Myeloid proliferations and neoplasms
Myeloid precursor lesions

1. Clonal haematopoiesis
2. Clonal cytopenias of undetermined significance

Myeloproliferative neoplasms

1. Myeloproliferative neoplasms
2. Introduction
3. Chronic myeloid leukaemia
4. Chronic neutrophilic leukaemia
5. Chronic eosinophilic leukaemia
6. Polycythaemia vera
7. Essential thrombocythaemia
8. Primary myelofibrosis
9. Juvenile myelomonocytic leukaemia
10. Myeloproliferative neoplasm, NOS

Mastocytosis

1. Introduction
2. Cutaneous mastocytosis
3. Systemic mastocytosis
4. Mast cell sarcoma

Myelodysplastic neoplasms

1. Introduction
2. Myelodysplastic neoplasms, with defining genetic abnormalities
3. Myelodysplastic neoplasm with low blasts and 5q deletion
4. Myelodysplastic neoplasm with low blasts and SF3B1 mutation
5. Myelodysplastic neoplasm with biallelic TP53 inactivation
6. Myelodysplastic neoplasms, morphologically defined
7. Myelodysplastic neoplasm with low blasts
8. Myelodysplastic neoplasm, hypoplastic
9. Myelodysplastic neoplasm with increased blasts
10. Myelodysplastic neoplasms of childhood
11. Childhood myelodysplastic neoplasm with low blasts
12. Childhood myelodysplastic neoplasm with increased blasts

Acute myeloid leukaemia
Introduction
Acute myeloid leukaemia with defining genetic abnormalities

1. Acute promyelocytic leukaemia with PML::RARA fusion
2. Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion
3. Acute myeloid leukaemia with CBFB::MYH11 fusion
4. Acute myeloid leukaemia with DEK::NUP214 fusion
5. Acute myeloid leukaemia with RBM15::MRTFA fusion
6. Acute myeloid leukaemia with BCR::ABL1 fusion
7. Acute myeloid leukaemia with KMT2A rearrangement
8. Acute myeloid leukaemia with MECOM rearrangement
9. Acute myeloid leukaemia with NUP98 rearrangement
10. Acute myeloid leukaemia with NPM1 mutation
11. Acute myeloid leukaemia with CEBPA mutation
12. Acute myeloid leukaemia, myelodysplasia-related
13. Acute myeloid leukaemia with other defined genetic alterations

Acute myeloid leukaemia, defined by differentiation

1. Acute myeloid leukaemia with minimal differentiation
2. Acute myeloid leukaemia without maturation
3. Acute myeloid leukaemia with maturation
4. Acute basophilic leukaemia
5. Acute myelomonocytic leukaemia
6. Acute monocytic leukaemia
7. Acute erythroid leukaemia
8. Acute megakaryoblastic leukaemia
9. Myeloid sarcoma

Myeloid neoplasms, secondary
Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions

1. Introduction
2. Myeloid neoplasm post cytotoxic therapy
3. Myeloid neoplasms associated with germline predisposition
4. Myeloid proliferations associated with Down syndrome

Myeloid/lymphoid neoplasms
Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement

1. Introduction
2. Myeloid/lymphoid neoplasm with PDGFRA rearrangement
3. Myeloid/lymphoid neoplasm with PDGFRB rearrangement
4. Myeloid/lymphoid neoplasm with FGFR1 rearrangement
5. Myeloid/lymphoid neoplasm with JAK2 rearrangement
6. Myeloid/lymphoid neoplasm with FLT3 rearrangement
7. Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion
8. Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes

Acute leukaemias of mixed or ambiguous lineage

1. Introduction
2. Acute leukaemia of ambiguous lineage with defining genetic abnormalities
3. Mixed-phenotype acute leukaemia with BCR::ABL1 fusion
4. Mixed-phenotype acute leukaemia with KMT2A rearrangement
5. Acute leukaemia of ambiguous lineage with other defined genetic alterations

Acute leukaemia of ambiguous lineage, immunophenotypically defined

1. Mixed-phenotype acute leukaemia, B/myeloid
2. Mixed-phenotype acute leukaemia, T/myeloid
3. Mixed-phenotype acute leukaemia, rare types
4. Acute leukaemia of ambiguous lineage, NOS
5. Acute undifferentiated leukaemia
6.