Description:

This course provides advanced updates on hematopathology focusing on the classification of Haematolymphoid Tumours according to the WHO 5th edition. Part 11 covers an introduction to B-cell Lymphoproliferative lesions, including their morphology, immunophenotype, molecular genetics, and clinical significance.

Key Highlights:

• the Spectrum of B-Cell Proliferations
• Relating Lymphomas to Normal B-Cell Development
• Germinal Center Reactions: Fine-Tuning the Antibody Response
• Post-Germinal Center B-Cell Fates
• Transcriptional Regulation of Early B-Cell Maturation
• Transcriptional Regulation in the Germinal Center (GC)
• Signals Driving Differentiation into Plasma Cells
• Alternative Fate: Memory B-Cell Differentiation
• Impact of Microenvironment on B-Cell Maturation (Bone Marrow)
• Impact of Microenvironment on B-Cell Maturation (Peripheral Lymphoid Organs)
• Characteristic Genetic/Genomic Changes in B-Cell Lymphomas
• Characteristic Mutations and Copy Number ChangesImpact of Ontogeny on Classification of B-Cell Lymphomas
• Characteristic Gene Expression Profiles and BCR Stereotypy
• The Complexity of Lymphomagenesis: Beyond Single Driver Mutations
• Key Aetiopathogenetic Factors in B-Cell Lymphomas
• Erroneous IG Gene Recombination and Chromosomal Translocations
• Principles of Classification, Subtyping, and Work-up
• Practice of Lymphoma Classification in Resource-Limited Settings
• Structure of the 5th Edition WHO Classification and Resource Limitations
• Conclusion 

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